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Antioxidant mechanisms and bioactivity of phenolic compunds found in Dioscorea Bulbifera
| Title: | Antioxidant mechanisms and bioactivity of phenolic compunds found in Dioscorea Bulbifera. |
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| Name(s): | Rees, Patricia Elizabeth, author. | |
| Type of Resource: | text | |
| Genre: |
Bibliography Text-txt Academic Theses. Academic Theses Electronic Thesis Or Dissertation. |
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| Issuance: | monographic | |
| Other Date: | 2018. | |
| Publisher: | University of West Florida, | |
| Place of Publication: | Pensacola, Florida : | |
| Physical Form: | electronic resource | |
| Extent: | 1 online resource (ix, 53 leaves : charts) | |
| Language(s): | eng | |
| Abstract: | Accumulation of oxidative damage has been implicated in numerous diseases bringing antioxidant investigations and plant phenolics to the forefront of medicinal research. The species Dioscorea bulbifera has been used in both traditional and modern medicinal systems and has good overall antioxidant capacity. Yet little work has been done to assess which chemical components may contribute to this action. The goals of this study were to investigate the antioxidant activity of individual phenolic compounds in the plant D. bulbifera; to compare the in vitro antioxidant assays with human cell studies; for this information to contribute to future investigations in treating human disease. Methanolic extracts of the D. bulbifera bulbils were analyzed using HPLC-MS/MS and NMR. Positively identified compounds were used for in vitro antioxidant assays (Ferric Reducing Antioxidant Power (FRAP), iron chelation, and Oxygen Radical Absorbance Capacity (ORAC), followed by human cell assays. Several phenolic species were tentatively identified. (+)-catechin was positively identified and used for further testing. In vitro assays showed potential for electron transfer antioxidant activity but not iron chelation. The hydrogen transfer mechanisms could not be assessed due to assay complications. Cell assays also suffered complications rendering them inconclusive. | |
| Identifier: | 1129599262 (oclc), WFE0000671 (IID) | |
| Note(s): |
by Patricia Elizabeth Rees. College of Science and Engineering; Department of Biology. Thesis (M.S.) University of West Florida 2018 Includes bibliographical references. Also available in print. |
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| Subject(s): |
University of West Florida Antioxidants Plant phenology |
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| Library Classification: | LD1807.F62k 2018 R447 | |
| Persistent Link to This Record: | Read full text online | |
| Use and Reproduction: | http://rightsstatements.org/vocab/InC-EDU/1.0/ | |
| Host Institution: | UWF | |
| Other Format: |
Antioxidant mechanisms and bioactivity of phenolic compunds found in Dioscorea Bulbifera. (Print version:) (OCoLC)1129599600 |
