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- Title
- Characterizing the effects of atypical antipsychotics on the neutrophil model cell line, PLB-985.
- Author
- Robbs, Emily J.
- Abstract/Description
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Atypical antipsychotics (AAPs) are a class of drug used to treat several mental diseases like bipolar disorder, obsessive-compulsive disorder, and schizophrenia. However, these substances are also known to cause a rare, yet severe and sometimes fatal syndrome known as neutropenia. Neutropenia (and its more acute form, agranulocytosis) is characterized by a significant decrease in an individual's circulating neutrophils--the most abundant white blood cell. Neutrophils are essential for proper...
Show moreAtypical antipsychotics (AAPs) are a class of drug used to treat several mental diseases like bipolar disorder, obsessive-compulsive disorder, and schizophrenia. However, these substances are also known to cause a rare, yet severe and sometimes fatal syndrome known as neutropenia. Neutropenia (and its more acute form, agranulocytosis) is characterized by a significant decrease in an individual's circulating neutrophils--the most abundant white blood cell. Neutrophils are essential for proper innate immunity, and depletion can result in higher risk of developing life-threatening illnesses. How atypical antipsychotics induce neutropenia is not well-understood, though research is ongoing. In this study, we aim to characterize the effects of four AAPs--clozapine, olanzapine, quetiapine and aripiprazole--on PLB-985 cell viability, as assessed by the XTT Cell Viability Assay. We found that only aripiprazole is able to significantly decrease dPLB-985 cell viability after 48-hour treatment. We hypothesized that aripiprazole's negative effect on cell viability is through its unique mechanism of action as a partial dopamine agonist; however, our results suggest that aripiprazole's effects are independent of dopamine receptor agonism.
Show less - Identifier
- 1294639220, WFE0000774
- Format
- Document (PDF)
- Title
- Control of hybrid generation microgrids based on consensus algorithm.
- Author
- Albaz, Rakan Khaled Kamal
- Abstract/Description
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Utility grid companies are currently facing many challenges. These challenges include energy management, efficiency, and power quality issues. It is well known that improving power systems' management, control, and quality results in better economic benefits, increased electronic device lifetime, and reduced power interruptions, leading to the satisfaction of utility and consumer. Many research efforts were done in the past decades focusing on power systems control, quality, and management....
Show moreUtility grid companies are currently facing many challenges. These challenges include energy management, efficiency, and power quality issues. It is well known that improving power systems' management, control, and quality results in better economic benefits, increased electronic device lifetime, and reduced power interruptions, leading to the satisfaction of utility and consumer. Many research efforts were done in the past decades focusing on power systems control, quality, and management. The need for more green energy resources has inspired these researchers to find ways to integrate renewable energy resources into the grid. The current grid is facing issues due to a number of reasons such as increased Distributed Energy Resources (DERs) types and number, increased loads' types and number, and the increased distance between the DERs, loads, and the grid. The study of this thesis aims at finding creative energy management and control solutions through observing and understanding the characteristics of the utility grid and implement these solutions in a simulation software called MATLAB/Simulink. Consensus-based control will be implemented in a hybrid generation microgrid which will support the grid and work on restoring voltage and frequency levels with optimum power sharing between the DER.
Show less - Identifier
- 1295678222, WFE0000777
- Format
- Document (PDF)
- Title
- Growing pains: investigating satellite tag epoxy attachments on juvenile turtles.
- Author
- Vidal, Alexander
- Abstract/Description
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While nesting behavior of sea turtles is well understood, gaps in knowledge exist for inwater movements. This is especially true for neonate and small juvenile turtles, which are overall data poor at pelagic and early neritic stages. The use of satellite-linked platform terminal transmitters (PTTs) allows scientists to study sea turtle movements; however, long-term tracking of sea turtles comes with a unique set of challenges. Tracking durations can be brief and limited by technical failures....
Show moreWhile nesting behavior of sea turtles is well understood, gaps in knowledge exist for inwater movements. This is especially true for neonate and small juvenile turtles, which are overall data poor at pelagic and early neritic stages. The use of satellite-linked platform terminal transmitters (PTTs) allows scientists to study sea turtle movements; however, long-term tracking of sea turtles comes with a unique set of challenges. Tracking durations can be brief and limited by technical failures. Most PTTs on small juveniles fail within one year. There is a general consensus among many biologists who tag small juvenile turtles that tags are failing due to premature detachment from carapace expansion. I tested this growth-caused detachment hypothesis through a series of controlled experiments. First, using empty red-eared slider (Trachemys scripta elegans) shells, I conducted axial load testing with model transmitters attached. Second, using juvenile red-eared sliders with model PTTs, I recreated the stress of shell growth on the epoxied-tag attachment. In both experiments, a suite of epoxies were tested, expansion factors were measured, and data was compared to sea turtle growth rates. This research contributes to the knowledge of how adhesives interact with a growing turtle shell.
Show less - Identifier
- 1294313663, WFE0000769
- Format
- Document (PDF)
- Title
- Shipwreck Tagging Archaeological Management Program (STAMP): a model for coastal heritage management based on community engagement and Citizen Science.
- Author
- Burkhard, Austin Leonard
- Abstract/Description
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The Florida Public Archaeological Network began the Shipwreck Tagging Archaeological Management Program (STAMP) in 2019 and utilizes citizen scientists to assist archaeologists in tracking the movement and degradation of beached/coastal shipwreck sites and disarticulated timbers. Historically Florida's coastal regions have been some of the most treacherous navigable waterways for mariners due to high wave turbidity, oceanic currents, and meteorological phenomena. As such, thousands of ships...
Show moreThe Florida Public Archaeological Network began the Shipwreck Tagging Archaeological Management Program (STAMP) in 2019 and utilizes citizen scientists to assist archaeologists in tracking the movement and degradation of beached/coastal shipwreck sites and disarticulated timbers. Historically Florida's coastal regions have been some of the most treacherous navigable waterways for mariners due to high wave turbidity, oceanic currents, and meteorological phenomena. As such, thousands of ships have ultimately met their demise along Florida coasts. The program, partnering with the National Park Service at Gulf Islands National Seashore, has collected data in the continued enhancement of public archaeological programs.
Show less - Date Issued
- 2020, 2020
- Identifier
- 1233072902, WFE0000746
- Format
- Document (PDF)
- Title
- Side channel attacks and device vulnerabilities: methodologies of attack and prevention.
- Author
- Easley, Ronda Rae
- Abstract/Description
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Side channel attacks are methods by which the encrypted data on a device or network can be obtained through observation and manipulation of the unintended outputs of the device such as power or electromagnetic radiation fluctuations, timing variances, or even discrepancies in sound or acoustic levels while the device is processing cryptographic functions. These attacks have become more prevalent as internet-of-things (IoT) devices have become more commonplace. Often the priorities in the...
Show moreSide channel attacks are methods by which the encrypted data on a device or network can be obtained through observation and manipulation of the unintended outputs of the device such as power or electromagnetic radiation fluctuations, timing variances, or even discrepancies in sound or acoustic levels while the device is processing cryptographic functions. These attacks have become more prevalent as internet-of-things (IoT) devices have become more commonplace. Often the priorities in the manufacture of such devices are compact size and low power consumption. Meeting these design parameters leads builders to insert less security measures into both the device hardware and the encryption software. Prior research details both the attack methods and countermeasure strategies that can be deployed during the design phase to offer higher security to the device. The research within this thesis defines and details the known methods of side channel attacks and identifies the intrinsic vulnerabilities of specific device types and encryption methods. This work further offers a tabular representation of the research which can be utilized by builders to identify vulnerabilities and recognize appropriate countermeasures.
Show less - Identifier
- 1298604408, WFE0000789
- Format
- Document (PDF)
- Title
- Vergil in the "Wracke" and the "Comming to Virginia": William Strachey's structural, literary, and ideological adaptation of the Aeneid.
- Author
- Scott, Teresa Yates
- Abstract/Description
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This paper investigates William Strachey's A True Reportory, a stylized eyewitness account of Strachey's 1609-1610 voyage to the Jamestown colony, showing how the text utilizes Vergil's Aeneid to set a precedent for the British colonization of the New World. By using the Aeneid as a resource for A True Reportory, I argue that Strachey is committed to creating a new and active history for Jamestown by connecting the ongoing foundation of Jamestown to that of the Roman Empire, an empire...
Show moreThis paper investigates William Strachey's A True Reportory, a stylized eyewitness account of Strachey's 1609-1610 voyage to the Jamestown colony, showing how the text utilizes Vergil's Aeneid to set a precedent for the British colonization of the New World. By using the Aeneid as a resource for A True Reportory, I argue that Strachey is committed to creating a new and active history for Jamestown by connecting the ongoing foundation of Jamestown to that of the Roman Empire, an empire destined for greatness, in the attempt to align his account with the promotional goals of the Virginia Company. In particular, I will show that Strachey leverages Rome's greatness to induce the British population to take a more active role in the larger North American colonial project, while also using uniquely Roman paradigms of colonialism to legitimize Britain's possession of Jamestown and place the British experience within a known colonial framework.
Show less - Identifier
- 1296381331, WFE0000779
- Format
- Document (PDF)